Binders are excipients that are used in the formulation of tablets to hold the other ingredients together. Binder excipients are important for the mechanical strength of tablets and for the volume of low-active-dose tablets. Here are some examples of binder excipients:
Starch
The use of starch as a binder in tablet formulations has numerous benefits. Its bulk density is an important characteristic that is related to the functional properties of the excipient. This property is measured by the Carr’s index or the Hausner ratio. Values lower than one indicate good flow, while those greater than one indicate poor flow. To find out whether starch is the right binder for your tablet formulation, follow the tips provided by these experts.
Microcrystalline cellulose
Historically, gelatin has been used as a binder in tablet formulation. However, gelatin has a greater tendency to agglomerate particles, forming liquid bridges that increase the size of the final product. Microcrystalline cellulose, on the other hand, has very low agglomeration potential, and can be used to make tablets with minimal agglomeration force, Browse around this site.
Natural polymers
Natural polymers are considered a safer and more economical alternative to synthetic polymers for binders in tablets. Gums and mucilage, which are abundant in nature, are used as natural excipients in the pharmaceutical industry. They also have fewer side effects and are biodegradable. These polymers improve the properties of the tablet and are environmentally friendly. They also provide a nutritional supplement.
Starch 1500
In tablet formulation, multifunctional starch composition can be used as a binder, and it has excellent disintegration properties comparable to other common starch excipients. Moreover, it can be combined with at least one other excipient to achieve the desired properties. Such properties may include crushability, friability, dissolution, and bioavailability. To achieve these desired properties, a suitable multifunctional starch composition should possess the following properties:
Pregelatinized starch
Traditionally, pregelatinized starch has been the binder of choice in the formulation of oral-sustained-release tablets. It is derived from corn, partially hydrolyzed, and dried. The pregelatinization process imparts superior binding properties to starch. Its secondary function is as a disintegrant. During ingestion, starch granules swell due to the fluid environment in the stomach. This swelling causes tablet breakage.
Natural gum olibanum
Using natural gum olibanum as a binger in tablet formulation has several benefits. This substance has a unique ability to enhance tablet stability and improve the patient experience. This gum is obtained by removing water from plant sources such as tapioca. Studies involving natural gums have shown that they can be a safer alternative to synthetic polymers such as PVP. To learn more about the benefits of using natural gum olibanum, read on.